(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile - High-Purity Chiral Intermediate from China Suppliers and Factory
Product Description
(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile is a high-purity chiral intermediate essential for the pharmaceutical industry. This off-white to light yellow solid is a primary building block in the synthesis of DPP-4 inhibitors, specifically the anti-diabetic medication Vildagliptin. Its precise (2S)-configuration ensures the correct stereochemistry required for biological activity. Engineered for high reactivity and stability, it allows for efficient coupling with various amines. This intermediate is indispensable for manufacturers focused on high-yield production of advanced pharmaceutical ingredients (APIs) and specialized heterocyclic synthesis.
Physical & Chemical Properties
| Product Category | Pyridine and Heterocyclic Pharmaceutical Intermediate |
| Appearance | White to Light yellow to Light orange powder to crystal |
| Melting Point | 52-53 °C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Optical Rotation | Consistent with structure |
| Boiling Point | 363.1±37.0 °C (Predicted) |
| Density | 1.27±0.1 g/cm³ (Predicted) |
| pKa | -4.65±0.40 (Predicted) |
Product Features
Key API Intermediate
Specifically designed for the synthesis of Vildagliptin and other related DPP-4 inhibitors for diabetes management.
High Chiral Purity
Maintained with strict enantiomeric control (typically ee over 99%) to ensure the efficacy of the final pharmaceutical product.
Optimal Reactivity
The chloroacetyl group provides a highly reactive site for efficient nucleophilic substitution and peptide-like bonding.
Consistent Quality
Produced under rigorous quality control standards to minimize impurities that could interfere with downstream catalytic processes.
Standardized Physical Form
Supplied as a stable crystalline powder, facilitating accurate weighing and handling in large-scale production.
Reliable Storage Stability
Formulated to remain stable under recommended cool and dry conditions for extended shelf life.
Packaging & Specifications
Packaging Specifications
Sample: 1g / 5g / 10g in glass bottles (inner sealing).
Bulk: 25kg in cardboard drums (vacuum aluminum foil inner bag).
Packaging Customization
Neutral packaging or customer-specified brand packaging is supported; prior communication and confirmation are required.
Storage Conditions
Store in a cool, dark environment (< 15°C), sealed under inert gas atmosphere. Avoid oxidizing agents and moisture.
Shelf Life
18 months shelf life when stored in original, sealed packaging under recommended conditions.
Quality Compliance & Assurance
Supply Service & Description
Supply Capacity
Annual capacity of 50 tons. In-stock products ship within 72 hours; customized synthesis orders deliver within 7-15 working days.
Shipping Options
Samples: Express (DHL/UPS, 3-7 days).
Bulk: Air/Sea freight (e.g., Maersk) with complete customs declaration documentation.
Payment Terms
Sample orders: 100% prepayment.
Bulk orders: T/T (30% deposit, 70% against B/L copy). L/C terms are negotiable.
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Frequently Asked Questions (FAQ)
The chiral purity remains ≥99% in mass production, and we provide chiral HPLC detection reports and COA for each batch.
Free 1g samples are available for quality evaluation, and customers only need to cover the international shipping cost.
Regular in-stock orders are dispatched within 72 hours, while tailored or larger contract manufacturing orders are delivered within 7-15 working days.
It must be kept in a sealed container under an inert gas atmosphere at temperatures below 15°C, away from moisture and strong oxidizing agents.
Yes, we support neutral packaging as well as customized client-specified labeling upon prior confirmation during order placement.
We supply a complete regulatory document package including Certificate of Analysis (COA), MSDS, packing list, commercial invoice, and relevant customs clearance documentation.