(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
Physical & Chemical Properties
| Product Category | Pyridine and Heterocyclic Pharmaceutical Intermediate | ||||||
| Appearance | White to Light yellow to Light orange powder to crystal | ||||||
| Melting Point | 52-53 °C | ||||||
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | ||||||
| Optical Rotation | Consistent with structure | ||||||
| Boiling point | 363.1±37.0 °C(Predicted) | ||||||
| Density | 1.27±0.1 g/cm3(Predicted) | ||||||
| pKa | -4.65±0.40(Predicted) | ||||||
Product Description
(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile is a high-purity chiral intermediate essential for the pharmaceutical industry. This off-white to light yellow solid is a primary building block in the synthesis of DPP-4 inhibitors, specifically the anti-diabetic medication Vildagliptin. Its precise (2S)-configuration ensures the correct stereochemistry required for biological activity. Engineered for high reactivity and stability, it allows for efficient coupling with various amines. This intermediate is indispensable for manufacturers focused on high-yield production of advanced pharmaceutical ingredients (APIs) and specialized heterocyclic synthesis.
Product Features
Key API Intermediate: Specifically designed for the synthesis of Vildagliptin and other related DPP-4 inhibitors for diabetes management.
High Chiral Purity: Maintained with strict enantiomeric control (typically ee over 99%) to ensure the efficacy of the final pharmaceutical product.
Optimal Reactivity: The chloroacetyl group provides a highly reactive site for efficient nucleophilic substitution and peptide-like bonding.
Consistent Quality: Produced under rigorous quality control standards to minimize impurities that could interfere with downstream catalytic processes.
Standardized Physical Form: Supplied as a stable crystalline powder, facilitating accurate weighing and handling in large-scale production.
Reliable Storage Stability: Formulated to remain stable under recommended cool and dry conditions for extended shelf life.
Packaging & Specifications
Packaging Specifications
Sample packaging: 1g/5g/10g in glass bottles (with inner sealing);
Bulk packaging: 25kg in cardboard drums (inner packaging with vacuum aluminum foil bags).
Packaging Customization
Neutral packaging or customer-specified brand packaging is supported; prior communication and confirmation are required.
Storage Conditions
Store in a cool and dark environment (temperature < 15°C), sealed under an inert gas atmosphere. Avoid contact with oxidizing agents and prevent moisture absorption.
Shelf Life
18 months shelf life when stored in original packaging (sealed condition).
Quality Compliance & Assurance
Supply Service & Description
Supply Capacity
Supply capacity: Annual production capacity of 50 tons. Popular products are usually in stock (in-stock orders shipped within 72 hours); customized orders are delivered within 7-15 working days based on process requirements.
Shipping options
Samples: DHL/UPS international express (3-7 days delivery);
Bulk cargo: Cooperate with logistics providers (e.g., Maersk) via sea/air freight. Full set of customs declaration documents are provided to ensure compliant customs clearance.
Payment terms
Sample orders: 100% prepayment;
Bulk orders: T/T (30% deposit, 70% payment against copy of bill of lading). L/C payment terms are negotiable.
Related & Extended Content
Recommended related products
(R)-3-Boc-aminopiperidine (CAS: 309956-78-3), Alogliptin benzoate (CAS: 850649-62-6)
Frequently Asked Questions（FAQ）
Q1: Is the product's chiral purity stable for large - scale production?
A1: The chiral purity remains ≥99% in mass production, and we provide chiral detection reports for each batch.
Q2: Can samples be provided before bulk procurement?
A2: Free 1g samples are available, and customers only need to bear the shipping cost.