3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one（CAS No.881386-01-2）
Density
1.50
Boiling Point
520.2±50.0 °C (Predicted)
Refractive Index
1.620
Flash Point
268.4±30.1 °C
Vapor Pressure
0.0±1.4 mmHg at 25°C
Form
Solid
PSA
66.13000
logP
1.86
Color
Light yellow to deep yellow
Acid Dissociation Constant (pKa)
-7.38±0.40 (Predicted)
Solubility
Slightly soluble in chloroform; slightly soluble in methanol (with sonication)
Storage Temperature
2–8°C
What is the main application of the product?
It is a key pharmaceutical intermediate for the synthesis of Apixaban (oral selective FXa inhibitor, cardiovascular drug). The gem-dichloro group at C3 enables nucleophilic substitution to construct the piperidinone core.
What are the appearance and physicochemical solubility properties?
Form: Solid; Color: Light yellow to deep yellow solid
Solubility: Slightly soluble in chloroform; slightly soluble in methanol (sonication required); practically insoluble in water