D-Proline
Physical & Chemical Properties
| Product Category | Amino Acid Pharmaceutical Intermediate | ||||||
| Appearance | White to off-white powder | ||||||
| Melting Point | 223℃ | ||||||
| Solubility | Methanol (Slightly), Water (Sparingly) | ||||||
| Optical Rotation | [α]22/D +85.0°, c = 4 in H2O | ||||||
| Water Solubility | soluble >1000 g/L (20 ℃) | ||||||
| Density | 1.19 | ||||||
| Boiling point | 252.2 ℃ at 760 mmHg | ||||||
| Refractive index | 85 ° (C=4, H2O) | ||||||
| Flash Point | 106.3 ℃ | ||||||
| Vapour Pressure | 0.0±1.1 mmHg at 25℃ | ||||||
| pKa | 1.952(at 25℃) | ||||||
Product Description
D-Proline is a high-purity, non-proteinogenic amino acid that serves as a vital chiral building block in modern chemical synthesis. As the optical isomer of the naturally occurring L-Proline, this white to off-white crystalline powder is indispensable for the creation of chiral ligands, catalysts, and specialized pharmaceuticals. Its unique secondary amine structure allows it to provide precise stereochemical control in asymmetric synthesis, making it a favorite among research chemists and drug developers.
Product Features
High Optical Purity: Guaranteed high enantiomeric excess (typically ee over 99%), ensuring maximum precision and selectivity in asymmetric catalytic reactions.
Versatile Chiral Building Block: Acts as a fundamental intermediate for synthesizing D-type peptides, chiral drugs, and advanced organic molecules.
Excellent Solubility: Highly soluble in water and slightly soluble in ethanol, allowing for flexible processing in various aqueous or organic solvent systems.
Stable Crystalline Form: Provided as a stable crystalline powder with a melting point of approximately 215 to 223 degrees Celsius (with decomposition), facilitating easy storage and handling.
Organocatalysis Essential: Widely utilized in the synthesis of chiral catalysts, such as those used in the Hajos-Parrish-Eder-Sauer-Wiechert reaction.
Pharmaceutical Grade Quality: Manufactured under strict quality control to ensure low heavy metal content and minimal impurities, suitable for pharmaceutical research.
Natural Isomer Alternative: Provides the necessary structural "mirror image" for researchers investigating the biological effects of D-amino acids in protein engineering.
Packaging & Specifications
Packaging Specifications
Sample packaging: 1g/5g/10g in glass bottles (with inner sealing);
Bulk packaging: 25kg in cardboard drums (inner packaging with vacuum aluminum foil bags).
Packaging Customization
Neutral packaging or customer-specified brand packaging is supported; prior communication and confirmation are required.
Storage Conditions
Store in a cool and dark environment (temperature < 15°C), sealed under an inert gas atmosphere. Avoid contact with oxidizing agents and prevent moisture absorption.
Shelf Life
18 months shelf life when stored in original packaging (sealed condition).
Quality Compliance & Assurance
Supply Service & Description
Supply Capacity
Supply capacity: Annual production capacity of 50 tons. Popular products are usually in stock (in-stock orders shipped within 72 hours); customized orders are delivered within 7-15 working days based on process requirements.
Shipping options
Samples: DHL/UPS international express (3-7 days delivery);
Bulk cargo: Cooperate with logistics providers (e.g., Maersk) via sea/air freight. Full set of customs declaration documents are provided to ensure compliant customs clearance.
Payment terms
Sample orders: 100% prepayment;
Bulk orders: T/T (30% deposit, 70% payment against copy of bill of lading). L/C payment terms are negotiable.
Related & Extended Content
Recommended related products
(R)-3-Boc-aminopiperidine (CAS: 309956-78-3), Alogliptin benzoate (CAS: 850649-62-6)
Frequently Asked Questions（FAQ）
Q1: Is the product's chiral purity stable for large - scale production?
A1: The chiral purity remains ≥99% in mass production, and we provide chiral detection reports for each batch.
Q2: Can samples be provided before bulk procurement?
A2: Free 1g samples are available, and customers only need to bear the shipping cost.