L-Proline CAS 147-85-3 | Chiral L-Proline Supplier & Factory in China - Pharmaceutical Intermediate
Physical & Chemical Properties
| Product Category | Amino Acid Pharmaceutical Intermediate |
| Appearance | White crystalline powder |
| Melting Point | 228℃ (dec.) (lit.) |
| Solubility | H₂O: 50 mg/mL |
| Optical Rotation | [α]20/D 85.0±1.0°, c = 5% in H₂O |
| Water Solubility | Soluble |
| Density | 1.35 |
| Boiling Point | 215.41℃ (rough estimate) |
| Refractive Index | -85° (C=4, H₂O) |
| Flash Point | 106.3℃ |
| Vapour Pressure | 0.0±1.1 mmHg at 25℃ |
| pKa | 1.95, 10.64 (at 25℃) |
Product Description
L-Proline is a high-purity, proteinogenic amino acid essential for the synthesis of collagen, the primary structural protein in skin, joints, and connective tissues. This white crystalline powder features a unique cyclic secondary amine structure, providing exceptional conformational rigidity to peptide chains. Widely used in the pharmaceutical, food, and cosmetic industries, L-Proline acts as a critical building block for anti-aging skin care, joint health supplements, and chiral catalysts in organic synthesis. Its high solubility and stability make it an ideal choice for manufacturers seeking consistent, high-performance ingredients for nutritional and medical formulations.
Product Features
- Collagen Precursor: Vital for skin elasticity, wound healing, and maintaining healthy joints and tendons.
- High Optical Purity: Enantiomeric purity typically ≥99%, ensuring precise results in chiral drug synthesis and research.
- Versatile Applications: Extensively used as a nutritional additive, pharmaceutical intermediate, and stabilizer in cosmetics.
- Superior Solubility: Easily dissolves in water (approx. 162g/100mL at 25°C), facilitating effortless formulation and processing.
- Stable & Reliable: Features high thermal stability with a melting point of 220–222°C, ideal for industrial storage and handling.
- Organic Catalyst: Acts as an efficient organocatalyst for asymmetric reactions like aldol condensations.
Packaging & Specifications
Packaging Specifications
Sample packaging: 1g / 5g / 10g in glass bottles (with inner sealing);
Bulk packaging: 25kg in cardboard drums (inner packaging with vacuum aluminum foil bags).
Packaging Customization
Neutral packaging or customer-specified brand packaging is supported; prior communication and confirmation are required.
Storage Conditions
Store in a cool and dark environment (temperature < 15°C), sealed under an inert gas atmosphere. Avoid contact with oxidizing agents and prevent moisture absorption.
Shelf Life
18 months shelf life when stored in original packaging (sealed condition).
Quality Compliance & Assurance
Supply Service & Description
Supply Capacity
Annual production capacity of 50 tons. Popular products are usually in stock (in-stock orders shipped within 72 hours); customized orders are delivered within 7–15 working days based on process requirements.
Shipping Options
Samples: DHL / UPS international express (3–7 days delivery);
Bulk cargo: Cooperate with logistics providers (e.g., Maersk) via sea / air freight. Full set of customs declaration documents provided to ensure compliant customs clearance.
Payment Terms
Sample orders: 100% prepayment;
Bulk orders: T/T (30% deposit, 70% payment against copy of bill of lading). L/C payment terms are negotiable.
Related & Extended Content
Frequently Asked Questions (FAQ)
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Q Is the product's chiral purity stable for large-scale production?The chiral purity remains ≥99% in mass production, and we provide chiral detection reports for each batch.
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Q Can samples be provided before bulk procurement?Free 1g samples are available, and customers only need to bear the shipping cost.
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Q What certifications and quality standards does your L-Proline meet?Our L-Proline complies with pharmaceutical-grade standards and is produced under strict GMP conditions. Full quality documentation including COA, MSDS, and batch-specific test reports are provided upon request.
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Q What is the minimum order quantity (MOQ) for bulk purchases?The MOQ for bulk orders is typically 1 kg. For larger volume requirements, please contact us directly to discuss pricing and availability tailored to your needs.
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Q How should L-Proline be handled and stored to maintain quality?L-Proline should be stored in a cool, dark environment at temperatures below 15°C, sealed under an inert gas atmosphere. Keep away from oxidizing agents and moisture. Under these conditions, the shelf life is 18 months in original sealed packaging.
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Q Do you support OEM or custom packaging for L-Proline?Yes, we support both neutral packaging and customer-specified brand packaging. OEM arrangements require prior communication and order confirmation. Please reach out to our team for detailed customization options.