Tenofovir Intermediate - Antiviral Pharmaceutical Supplier and Factory in China | CAS 147127-20-6
| Product Category | Antiviral Pharmaceutical Intermediates |
| Appearance | White Crystalline Solid |
| Melting Point | 276–280 ℃ |
| Solubility | Aqueous Acid (Sparingly), DMSO (Slightly, Heated), Water (Slightly, Heated) |
| Optical Rotation | [α]/D -20 to -26°, c = 0.5 in 1 M HCl |
| Water Solubility | H₂O: 13.4 mg/mL (25 ℃) |
| Density | 1.79 |
| Boiling Point | 616.1 ℃ at 760 mmHg |
| Refractive Index | 1.74 |
| Flash Point | 326.4 ℃ |
| Vapour Pressure | 0.0 ± 1.9 mmHg at 25 ℃ |
| pKa | 2.36 ± 0.10 (Predicted) |
Tenofovir is a potent nucleotide analog reverse transcriptase inhibitor (NRTI) used as a fundamental building block in antiviral therapy. This high-purity crystalline powder is primarily utilized to synthesize prodrugs like Tenofovir Disoproxil and Tenofovir Alafenamide, which are frontline treatments for HIV-1 and Chronic Hepatitis B. By blocking the viral DNA polymerase, it effectively inhibits viral replication. Its exceptional stability and proven efficacy make it an indispensable pharmaceutical intermediate for manufacturers producing life-saving medications and conducting advanced virology research worldwide.
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Core Antiviral ScaffoldServes as the essential active moiety for the development of major antiretroviral and anti-HBV medications.
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High Pharmaceutical GradeManufactured with an assay of 98% or higher, meeting strict regulatory requirements for pharmaceutical synthesis.
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Nucleotide Analog PrecisionDesigned to mimic natural substrates, providing targeted inhibition of viral reverse transcriptase enzymes.
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Proven StabilityExhibits excellent chemical and thermal stability, ensuring a reliable shelf life when stored under standard conditions.
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Optimized for ProdrugsFeatures a versatile phosphonate group, allowing for efficient esterification into more bioavailable drug forms.
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Consistent Particle SizeFine powder form allows for uniform blending and rapid dissolution during large-scale chemical processing.
Sample packaging: 1g / 5g / 10g in glass bottles (with inner sealing);
Bulk packaging: 25 kg in cardboard drums (inner packaging with vacuum aluminum foil bags).
Neutral packaging or customer-specified brand packaging is supported; prior communication and confirmation are required.
Store in a cool and dark environment (temperature < 15°C), sealed under an inert gas atmosphere. Avoid contact with oxidizing agents and prevent moisture absorption.
18 months shelf life when stored in original packaging (sealed condition).
Annual production capacity of 50 tons. Popular products are usually in stock (in-stock orders shipped within 72 hours); customized orders are delivered within 7–15 working days based on process requirements.
Samples: DHL / UPS international express (3–7 days delivery);
Bulk cargo: Cooperate with logistics providers (e.g., Maersk) via sea / air freight. Full set of customs declaration documents are provided to ensure compliant customs clearance.
Sample orders: 100% prepayment;
Bulk orders: T/T (30% deposit, 70% payment against copy of bill of lading). L/C payment terms are negotiable.