Tenofovir
Physical & Chemical Properties
| Product Category | Antiviral Pharmaceutical Intermediates | ||||||
| Appearance | White Crystalline Solid | ||||||
| Melting Point | 276-280℃ | ||||||
| Solubility: | Aqueous Acid (Sparingly), DMSO (Slightly, Heated), Water (Slightly, Heated) | ||||||
| Optical Rotation | [α]/D -20 to -26°, c = 0.5 in 1 M HCl | ||||||
| Water Solubility | H2O: 13.4 mg/mL (25 ℃) | ||||||
| Density | 1.79 | ||||||
| Boiling point | 616.1 ℃ at 760 mmHg | ||||||
| Refractive index | 1.74 | ||||||
| Flash Point | 326.4 ℃ | ||||||
| Vapour Pressure | 0.0±1.9 mmHg at 25℃ | ||||||
| pKa | 2.36±0.10(Predicted) | ||||||
Product Description
Tenofovir is a potent nucleotide analog reverse transcriptase inhibitor (NRTI) used as a fundamental building block in antiviral therapy. This high-purity crystalline powder is primarily utilized to synthesize prodrugs like Tenofovir Disoproxil and Tenofovir Alafenamide, which are frontline treatments for HIV-1 and Chronic Hepatitis B. By blocking the viral DNA polymerase, it effectively inhibits viral replication. Its exceptional stability and proven efficacy make it an indispensable pharmaceutical intermediate for manufacturers producing life-saving medications and conducting advanced virology research worldwide.
Product Features
Core Antiviral Scaffold: Serves as the essential active moiety for the development of major antiretroviral and anti-HBV medications.
High Pharmaceutical Grade: Manufactured with an assay of 98% or higher, meeting strict regulatory requirements for pharmaceutical synthesis.
Nucleotide Analog Precision: Designed to mimic natural substrates, providing targeted inhibition of viral reverse transcriptase enzymes.
Proven Stability: Exhibits excellent chemical and thermal stability, ensuring a reliable shelf life when stored under standard conditions.
Optimized for Prodrugs: Features a versatile phosphonate group, allowing for efficient esterification into more bioavailable drug forms.
Consistent Particle Size: Fine powder form allows for uniform blending and rapid dissolution during large-scale chemical processing.
Packaging & Specifications
Packaging Specifications
Sample packaging: 1g/5g/10g in glass bottles (with inner sealing);
Bulk packaging: 25kg in cardboard drums (inner packaging with vacuum aluminum foil bags).
Packaging Customization
Neutral packaging or customer-specified brand packaging is supported; prior communication and confirmation are required.
Storage Conditions
Store in a cool and dark environment (temperature < 15°C), sealed under an inert gas atmosphere. Avoid contact with oxidizing agents and prevent moisture absorption.
Shelf Life
18 months shelf life when stored in original packaging (sealed condition).
Quality Compliance & Assurance
Supply Service & Description
Supply Capacity
Supply capacity: Annual production capacity of 50 tons. Popular products are usually in stock (in-stock orders shipped within 72 hours); customized orders are delivered within 7-15 working days based on process requirements.
Shipping options
Samples: DHL/UPS international express (3-7 days delivery);
Bulk cargo: Cooperate with logistics providers (e.g., Maersk) via sea/air freight. Full set of customs declaration documents are provided to ensure compliant customs clearance.
Payment terms
Sample orders: 100% prepayment;
Bulk orders: T/T (30% deposit, 70% payment against copy of bill of lading). L/C payment terms are negotiable.
Related & Extended Content
Recommended related products
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Frequently Asked Questions（FAQ）
Q1: Is the product's chiral purity stable for large - scale production?
A1: The chiral purity remains ≥99% in mass production, and we provide chiral detection reports for each batch.
Q2: Can samples be provided before bulk procurement?
A2: Free 1g samples are available, and customers only need to bear the shipping cost.